Neuropathy: Understanding Nerve Damage, Finding Relief, and Treating the Underlying Cause

Numbness, Burning, Tingling or Pain Isn't Just Part of Getting Older

If you’re experiencing numbness, burning, tingling, stabbing pain, weakness, or loss of sensation in your feet or hands, you may be living with peripheral neuropathy.

Neuropathy affects millions of Americans and can make everyday activities—from walking and sleeping to driving and maintaining balance—more difficult and painful.

For many people, neuropathy is not a disease itself—it is a symptom of an underlying medical condition. Identifying and treating the cause is one of the most important steps in managing nerve damage and helping prevent it from progressing.

At Metabolic Centers for Excellence (MCE), we believe effective neuropathy care begins with understanding why the nerves are being damaged, not simply masking the symptoms.

What Is Neuropathy?

Peripheral neuropathy occurs when the nerves outside the brain and spinal cord become damaged.

These nerves control:

  • Touch and sensation
  • Temperature perception
  • Pain signals
  • Muscle movement
  • Balance and coordination
  • Blood vessel function
  • Sweating
  • Digestion
  • Heart rate
  • Bladder and bowel function

When nerves become damaged, they may stop sending signals correctly—or send pain signals even when there is no injury.

According to the National Institute of Neurological Disorders and Stroke, more than 20 million people in the United States are estimated to have some form of peripheral neuropathy, although the true number may be significantly higher.

What Causes Neuropathy?

Neuropathy has many possible causes. The most common include:

Diabetes is the leading cause of peripheral neuropathy.

Persistently elevated blood sugar can damage the small blood vessels that supply oxygen and nutrients to the nerves.

Approximately half of people living with diabetes will develop some degree of diabetic neuropathy during their lifetime.

Even before diabetes develops, elevated blood sugar and insulin resistance may begin damaging nerves.

Many patients are surprised to learn they have neuropathy before they have ever been diagnosed with diabetes.

Certain chemotherapy medications may injure peripheral nerves.

This condition, called chemotherapy-induced peripheral neuropathy (CIPN), can continue long after cancer treatment has ended.

Neuropathy may also result from:

  • Vitamin B12 deficiency
  • Autoimmune disorders
  • Kidney disease
  • Thyroid disorders
  • Alcohol misuse
  • Infections
  • Certain medications
  • Repetitive nerve compression
  • Traumatic injury
  • Hereditary nerve disorders
  • Poor circulation
  • Chronic inflammation
  • Unknown (idiopathic) causes

For some patients, more than one contributing factor is present.

Common Symptoms of Neuropathy

Symptoms vary depending on which nerves have been affected. Patients commonly report:

Sensory Symptoms

Motor Symptoms

Balance Problems

Autonomic Symptoms

Symptoms often begin gradually and may worsen over time if the underlying cause is not addressed.

Frequently Asked Questions

How Is Neuropathy Diagnosed?

No single test can diagnose every form of neuropathy.

A comprehensive evaluation may include:

  • Medical history
  • Physical examination
  • Neurological examination
  • Reflex testing
  • Sensory testing
  • Vibration testing
  • Monofilament testing
  • Balance assessment
  • Muscle strength evaluation
  • Blood sugar evaluation
  • Vitamin deficiency screening
  • Thyroid testing
  • Kidney function tests
  • Nerve conduction studies (when indicated)
  • Electromyography (EMG)
  • Imaging studies (when appropriate)

At MCE, we also evaluate metabolic factors that may contribute to nerve damage, including insulin resistance, blood sugar control, circulation, and overall metabolic health.

You should seek medical evaluation if you experience:

  • New numbness
  • Burning feet
  • Tingling hands
  • Progressive weakness
  • Balance problems
  • Frequent falls
  • Foot wounds that heal slowly
  • Pain that interferes with sleep
  • Symptoms that continue to worsen


Early evaluation offers the best opportunity to identify treatable causes and reduce the risk of further nerve damage.

Treatment depends on the underlying cause.

For many patients, treatment involves a combination of approaches.

Treating the Underlying Condition

The most important step is identifying and managing the condition causing the nerve damage.

Examples include:

  • Improving blood sugar control
  • Treating prediabetes or diabetes
  • Correcting vitamin deficiencies
  • Managing thyroid disease
  • Improving kidney health
  • Adjusting medications when appropriate
  • Treating autoimmune disorders


Prescription Medications

Your healthcare provider may prescribe medications to help reduce neuropathic pain, including:

  • Duloxetine (Cymbalta®)
  • Pregabalin (Lyrica®)
  • Gabapentin (Neurontin®)
  • Tricyclic antidepressants
  • Topical lidocaine
  • Capsaicin products

These medications may help reduce symptoms but generally do not reverse the underlying nerve damage.

Physical Therapy

Physical therapy may improve:

  • Strength
  • Balance
  • Mobility
  • Fall prevention
  • Walking mechanics


Lifestyle Changes

Patients are often encouraged to:

  • Improve blood sugar control
  • Exercise regularly
  • Stop smoking
  • Reduce alcohol intake
  • Maintain a healthy weight
  • Follow a nutrient-rich eating plan
  • Protect the feet from injury


Nutritional Support

Some patients with documented deficiencies may benefit from vitamin replacement, such as vitamin B12 or other nutrients, when medically appropriate.

How MCE Can Make the Difference

Many patients come to MCE after years of simply being told to “live with it.” Our philosophy is different. Rather than focusing only on pain management, we work to identify and address the metabolic and circulatory factors that may be contributing to nerve dysfunction.

Comprehensive Neuropathy Evaluation

Your evaluation may include:

Medical history review
Blood sugar assessment
A1C testing
Evaluation for insulin resistance

Circulation assessment
Balance evaluation
Foot examination
Neuropathy symptom assessment

Medication review
Review of previous treatments
Functional limitations
Lifestyle and nutrition assessment

MCE's Comprehensive Neuropathy Treatment Approach

Depending on your diagnosis and clinical needs, your personalized treatment plan may include:

Metabolic Infusion Therapy (MIT)

For appropriately selected patients with diabetes or insulin resistance, MCE offers medically supervised Metabolic Infusion Therapy (MIT). MIT uses carefully controlled, small-dose insulin/saline blend administration with continuous glucose monitoring as part of a comprehensive metabolic treatment plan. For eligible patients, improving metabolic health may be one component of an overall strategy to support nerve health. MIT is not appropriate for every patient and does not replace standard diabetes care.

Shockwave Therapy

Extracorporeal Shockwave Therapy uses acoustic energy to stimulate the body's natural healing response. Research suggests shockwave therapy may promote: Improved circulation, Cellular repair processes, Tissue regeneration, Improved function in appropriately selected patients

Class IV Laser Therapy

High-powered laser therapy delivers therapeutic light energy into affected tissues. Potential benefits may include: Temporary pain relief, Reduced inflammation, Improved circulation, Support for tissue healing

Nutritional and Metabolic Support

Nutrition plays an important role in overall nerve health. MCE provides individualized guidance focused on: Blood sugar management, Anti-inflammatory nutrition, Healthy weight management, Cardiovascular health, Metabolic wellness

Ongoing Monitoring

Throughout treatment, our team monitors your progress through: Symptom assessments, Functional improvements, Balance evaluations, Blood sugar trends (when applicable), Neuropathy testing, Follow-up examinations

Why Patients Choose MCE

Patients choose Metabolic Centers for Excellence because we strive to look beyond symptom management. Our approach emphasizes:

Identifying the underlying cause
Evaluating metabolic health
Comprehensive neuropathy assessments

Individualized treatment plans
Multiple evidence-informed
treatment options

Ongoing monitoring and education
Coordination with your primary care provider and specialists when appropriate

Hormonal, menstrual and fertility outcomes should be monitored with the appropriate reproductive-health provider.

Don't Ignore the Warning Signs

Neuropathy often progresses gradually. The earlier nerve damage is identified and the underlying causes are addressed, the greater the opportunity to preserve function, reduce symptoms, and improve quality of life.

If you are experiencing numbness, tingling, burning pain, balance problems, or diabetic nerve symptoms, our team can help determine the cause and discuss appropriate treatment options.

Medical Disclaimer

This webpage is intended for educational purposes only and should not replace medical advice from your healthcare provider. Neuropathy has many possible causes, and treatment should be individualized based on a comprehensive medical evaluation. MCE’s therapies, including Metabolic Infusion Treatment, Shockwave Therapy, and Class IV Laser Therapy, are offered only when clinically appropriate. Individual results vary, and no treatment can guarantee symptom improvement or reversal of nerve damage.